The stock exchanges in New York started trading on Thursday with small losses.
Investors on Wall Street are responding to the new figures for the US distributions of claims and the interest rate decision of the European Central Bank (ECB).
Furthermore, attention continues to be focused on the bickering between the United States and China and the demonstrations against police brutality and racism in various American cities.
Shortly after the opening bell, the Dow-Jones index was 0.3 percent in the minus at 26,208 points. The broad-based S&P 500 was lowered by 0.4 percent at 3,112 points, and tech exchange Nasdaq fell 0.2 percent to 9,667 points.
Another 1.9 million Americans filed for unemployment benefits last week.
This brings the counter of all Americans who used the safety net in the corona crisis to around 42 million. The figure is slightly lower than a week earlier, but more than the average economists had anticipated.
The ECB also launched a new round of stimuli in Europe.
The central bank has announced it will purchase additional bonds worth hundreds of billions of euros to mitigate the economic impact of the pandemic.